Epazote has a distinctively sharp, herbal flavor, reminiscent of oregano and fennel with minty, pine notes. Purchase this dried epazote for your Mexican dishes. Epazote is an annual or short-lived perennial plant that grows up to four feet tall. It is native to Southern Mexico, Central and South America. As well as its native. Jun 5, Epazote (pronounced eh-pah-ZOH-teh) is an aromatic herb commonly used in the cuisines and traditional medicines of central and southern.