Antidepressants are not very helpful and cause many side effects. These herbal remedies have a history of effectiveness and safety in treating depression. Medical Treatments for - The Top Herbal Remedies - Chamomile (Matricaria. These include the following herbs: Crataegus oxyacantha (hawthorn) Eschscholzia californica (California poppy) Ginkgo biloba. Lavandula angustifolia (lavender) Matricaria recutita (chamomile) Melissa officinalis (lemon balm) Passiflora incarnate (maypop, or purple passionflower) Piper methysticum (kava) St. John's wort - Omega-3 fatty acids - SAM-e. Dec 2, Also, if you are taking antidepressant medications, you should always check with your St. John's wort is the most studied herb of all time. Making a Natural Antidepressant Jun 25, Want to relieve your depression symptoms using safe, natural antidepressants? Want an herbal alternative that can improve your depression. Apr 20, This herb increased your resilience to physical and mental stress. and has fewer side effects than Zoloft, a common SSRI antidepressant (2). St John's Wort contains the active phytonutrient hypericin, which together with hyperforin, is one of the principal active constituents found in this herb. Many studies have found the herb to be equally as effective as traditional antidepressants, but with fewer side effects in mild to moderately depressed patients.